Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ACP3 | P15309 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313395 | 0.98 | SRC (0.48) | SRCACP3MEN1HTTKMT2A | |
| SCHEMBL29657146 | 0.77 | ALDH1A1 (0.44) | SRCACP3MEN1HTTKMT2A | |
| SCHEMBL9313408 | 0.76 | MEN1 (0.48) | SRCACP3MEN1HTTKMT2A | |
| SCHEMBL9315035 | 0.75 | LMNA (0.40) | ACP3MEN1HTTKMT2ASLC6A2 | |
| SCHEMBL9315020 | 0.73 | MAPT (0.67) | MEN1HTTKMT2A | |
| SCHEMBL8349435 | 0.73 | MEN1 (0.45) | SRCMEN1HTTKMT2ASLC6A2 | |
| SCHEMBL11776048 | 0.71 | MTOR (0.43) | SRCACP3 | |
| SCHEMBL10965528 | 0.70 | MEN1 (0.42) | SRCACP3MEN1HTTKMT2A | |
| SCHEMBL232244 | 0.69 | ACP3 (0.79) | SRCACP3 | |
| SCHEMBL1695685 | 0.68 | ROCK2 (0.53) | SRCSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5315035-A | Hydrogen peroxide detection | BOEHRINGER MANNHEIM GMBH (DE) | 1994-05-24 | — | — | US | disclosed |
| US-5084382-A | A color former with an oxidizable coupler for detection of hydrogen peroxide or hydrogen peroxide forming system or peroxidase or oxidizers for amine detection | BOEHRINGER MANNHEIM GMBH (DE) | 1992-01-28 | — | — | US | disclosed |
| US-4820632-A | ANILINE DERIVATIVE AND OXIDIZABLE COUPLER COLORED COMPOUND FOR DETECTION OF HYDROGEN PEROXIDE; MEDICAL DIAGNOSIS | BOEHRINGER MANNHEIM GMBH (DE) | 1989-04-11 | — | — | US | disclosed |