Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.67 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11699099 | 0.83 | EPHX1 (0.67) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4319424 | 0.80 | EPHX1 (1.00) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23453374 | 0.78 | SMN1; SMN2 (0.71) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2752957 | 0.78 | EPHX1 (0.97) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16762665 | 0.75 | SMN1; SMN2 (0.59) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL23406296 | 0.75 | EPHX1 (0.90) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16679027 | 0.74 | RAB9A (0.59) | EPHX1RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL11813529 | 0.73 | LMNA (0.64) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11815955 | 0.73 | LMNA (0.64) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL1999157 | 0.72 | NPC1 (0.70) | EPHX1EPHX2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5312840-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION (US) | 1994-05-17 | — | — | US | claimed |
| EP-0532642-A4 | — | — | 1994-04-27 | — | — | EP | claimed |
| EP-0532642-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1993-03-24 | — | — | EP | claimed |
| WO-1991018868-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) | 1991-12-12 | — | — | WO | claimed |