Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.36 |
| ▸ | KLK3 | P07288 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931611 | 0.85 | BACE1 (0.68) | BACE1KCNH2BACE2 | |
| SCHEMBL931716 | 0.82 | BACE1 (0.78) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL931601 | 0.77 | BACE1 (0.50) | BACE1KCNH2BACE2APPALDH1A1 | |
| SCHEMBL932038 | 0.69 | BACE1 (1.00) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL14951105 | 0.69 | KDM4E (0.48) | KLK3CHEK1ALDH1A1POLBHPGD | |
| SCHEMBL1075789 | 0.67 | BACE1 (0.74) | BACE1KCNH2BACE2APP | |
| SCHEMBL931151 | 0.67 | BACE1 (0.51) | BACE1KCNH2BACE2ALDH1A1POLB | |
| SCHEMBL931695 | 0.67 | BACE1 (0.70) | BACE1KCNH2BACE2APP | |
| SCHEMBL931135 | 0.67 | BACE1 (0.52) | BACE1KCNH2BACE2APPCTSD | |
| SCHEMBL931425 | 0.67 | BACE1 (0.52) | BACE1KCNH2BACE2APPHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |