Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315972 | 1.00 | ANPEP (0.46) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL9311100 | 1.00 | ANPEP (0.46) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL9311109 | 0.84 | ANPEP (0.43) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL8603774 | 0.80 | ANPEP (0.41) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL9316055 | 0.73 | ANPEP (0.68) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL9315989 | 0.73 | ANPEP (0.68) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL9564518 | 0.73 | ANPEP (0.68) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL9683270 | 0.72 | MMP2 (0.53) | MMP1MMP2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9747664 | 0.71 | MMP2 (0.53) | ANPEPERAP2MMP1MMP2KDM4E | |
| SCHEMBL10842273 | 0.71 | MMP2 (0.51) | ANPEPERAP2MMP1MMP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522576-A2 | Aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphospinic/phosphonic acids, process of their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-01-13 | — | — | EP | claimed |
| US-5364846-A | N-cycloalkylaminoethane-1,1-bis (phosphonic acid) useful for the treatment of osteoporosis and degenerative joint disease | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-15 | — | — | US | disclosed |
| EP-0522576-A2 | Aminoethane-1,1-bisphosphonic acids and aminoethane-1,1-alkylphospinic/phosphonic acids, process of their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-01-13 | — | — | EP | disclosed |