Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.33 |
| ▸ | RAC1 | P63000 | 1/20 | 0.31 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316280 | 0.90 | EPHX2 (0.40) | EPHX2EPHX1FAAHCNR2 | |
| SCHEMBL9316317 | 0.87 | RAC1 (0.39) | EPHX2EPHX1RAC1PAK1 | |
| SCHEMBL9317615 | 0.75 | SIGMAR1 (0.45) | EPHX2EPHX1CNR2 | |
| SCHEMBL9316314 | 0.73 | EPHX2 (0.36) | EPHX2EPHX1CNR2 | |
| SCHEMBL9316509 | 0.72 | EPHX2 (0.34) | EPHX2RAC1PAK1FAAHCNR2 | |
| SCHEMBL8952180 | 0.69 | SIGMAR1 (0.53) | EPHX2FAAHCNR2 | |
| SCHEMBL6719600 | 0.68 | SIGMAR1 (0.54) | EPHX2FAAHCNR2 | |
| SCHEMBL6717118 | 0.67 | SIGMAR1 (0.57) | EPHX2RAC1PAK1FAAH | |
| SCHEMBL8952043 | 0.66 | SIGMAR1 (0.56) | EPHX1 | |
| SCHEMBL8952040 | 0.66 | SIGMAR1 (0.56) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532642-A4 | — | — | 1994-04-27 | — | — | EP | claimed |
| EP-0532642-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1993-03-24 | — | — | EP | claimed |
| WO-1991018868-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) | 1991-12-12 | — | — | WO | claimed |