Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316291 | 0.90 | EPHX2 (0.33) | EPHX2EPHX1CNR2FAAH | |
| SCHEMBL9317615 | 0.84 | SIGMAR1 (0.45) | EPHX2EPHX1SIGMAR1TSHRNPC1 | |
| SCHEMBL8952180 | 0.77 | SIGMAR1 (0.53) | EPHX2SIGMAR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL6719600 | 0.76 | SIGMAR1 (0.54) | EPHX2SIGMAR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL9316317 | 0.75 | RAC1 (0.39) | EPHX2EPHX1SIGMAR1MAPT | |
| SCHEMBL8952043 | 0.74 | SIGMAR1 (0.56) | EPHX1SIGMAR1NPC1ALDH1A1LMNA | |
| SCHEMBL8952040 | 0.74 | SIGMAR1 (0.56) | EPHX1SIGMAR1NPC1ALDH1A1LMNA | |
| SCHEMBL6719371 | 0.73 | SIGMAR1 (0.57) | EPHX2EPHX1SIGMAR1NPC1ALDH1A1 | |
| SCHEMBL8741839 | 0.71 | TAS1R3 (0.49) | EPHX1SIGMAR1NPC1LMNARAB9A | |
| SCHEMBL8952184 | 0.67 | SIGMAR1 (0.44) | EPHX2SIGMAR1KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532642-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0532642-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018868-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) | 1991-12-12 | — | — | WO | disclosed |