Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716367 | 0.87 | ESR1 (0.38) | ESR1ESR2KDM4EHTTMEN1 | |
| SCHEMBL6717504 | 0.78 | HSD17B10 (0.38) | ESR1ESR2KDM4EHTTMEN1 | |
| SCHEMBL9317724 | 0.76 | HSD17B10 (0.43) | KDM4EHTTMEN1CYP3A4MAPT | |
| SCHEMBL6724468 | 0.75 | HSD17B10 (0.37) | ESR1ESR2KDM4EHTTMEN1 | |
| SCHEMBL6811148 | 0.70 | ESR1 (0.46) | ESR1ESR2KDM4EHTTMEN1 | |
| SCHEMBL6716430 | 0.70 | KYNU (0.40) | KDM4EHTTMEN1KMT2ATDP1 | |
| SCHEMBL27665577 | 0.70 | HSD17B10 (0.47) | KDM4EHTTMEN1CYP3A4MAPT | |
| SCHEMBL9316845 | 0.69 | ADRB2 (0.35) | KDM4EMEN1CYP3A4MAPTALOX15 | |
| SCHEMBL4148827 | 0.69 | HTT (0.42) | KDM4EHTTMEN1CYP3A4MAPT | |
| SCHEMBL27665666 | 0.68 | HSD17B10 (0.44) | ESR1ESR2KDM4EHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | claimed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | claimed |