Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 10/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316682 | 0.75 | BLM (0.40) | ADRB2KMT2AHIF1ALMNACASP7 | |
| SCHEMBL9316406 | 0.69 | ESR1 (0.38) | KMT2ACYP3A4TSHRCYP2C9BLM | |
| SCHEMBL9568397 | 0.68 | ARG1 (0.56) | KMT2ALMNACYP3A4TSHRBLM | |
| SCHEMBL1097800 | 0.68 | ARG1 (0.56) | KMT2ALMNACYP3A4TSHRBLM | |
| SCHEMBL6717504 | 0.68 | HSD17B10 (0.38) | KMT2ALMNACYP3A4CYP2C9BLM | |
| SCHEMBL28238488 | 0.66 | ODC1 (0.62) | KMT2ALMNABLMMEN1KDM4E | |
| SCHEMBL27665613 | 0.66 | BLM (0.41) | ADRB2KMT2AHIF1ALMNACASP7 | |
| SCHEMBL22077893 | 0.65 | BLM (0.40) | KMT2AHIF1ALMNATSHRCYP2C9 | |
| SCHEMBL27644447 | 0.65 | BLM (0.44) | ADRB2KMT2AHIF1ALMNACASP7 | |
| SCHEMBL12506358 | 0.64 | ARG1 (0.40) | KMT2ALMNACYP3A4TSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484437-A4 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | SEARLE & CO (US) | 1994-06-01 | — | — | EP | disclosed |
| EP-0484437-A1 | RENAL-SELECTIVE PRODRUGS FOR THE TREATMENT OF HYPERTENSION | G.D. Searle & Co. (US) | 1992-05-13 | — | — | EP | disclosed |