Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859892 | 0.79 | PTGS2 (0.57) | PDGFRBPDGFRAKDM4EALDH1A1POLB | |
| SCHEMBL9316811 | 0.78 | PDGFRB (0.50) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL9594608 | 0.78 | PDGFRB (0.50) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL10435155 | 0.72 | AXL (0.57) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL12356941 | 0.72 | AXL (0.61) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL30176381 | 0.72 | AXL (0.61) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL16756014 | 0.72 | AXL (0.53) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL8761856 | 0.71 | AXL (0.56) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL8760755 | 0.70 | LOXL2 (0.56) | PDGFRBPDGFRALOXL2KDM4EALDH1A1 | |
| SCHEMBL335235 | 0.69 | PDGFRB (0.79) | PDGFRBPDGFRAKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278166-A | 4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |