SCHEMBL9318192

SCHEMBL9318192

COC(=O)c1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
RARB P10826 5/20 0.46
RARG P13631 5/20 0.46
RARA P10276 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
NR1I2 O75469 1/20 0.46
LMNA P02545 1/20 0.46
PGR P06401 1/20 0.46
HSPD1 P10809 1/20 0.46
GOT1 P17174 1/20 0.46
GLRA1 P23415 1/20 0.46
BLM P54132 1/20 0.46
HSPE1 P61604 1/20 0.46
WDR5 P61964 1/20 0.44
DHODH Q02127 2/20 0.42
MAPT P10636 3/20 0.42
KDM4E B2RXH2 3/20 0.42
ALDH1A1 P00352 3/20 0.42
HPGD P15428 3/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9317943 0.90 WDR5 (0.51) MEN1KMT2ARARBRARGRARA
SCHEMBL4747624 0.88 RARB (0.61) MEN1KMT2ARARBRARGRARA
SCHEMBL8766629 0.86 RARB (0.42) MEN1KMT2ARARBRARGRARA
SCHEMBL7744702 0.85 RARB (0.58) MEN1KMT2ARARBRARGRARA
SCHEMBL8322288 0.84 RARB (0.49) MEN1KMT2ARARBRARGRARA
SCHEMBL9318241 0.84 RARB (0.48) MEN1KMT2ARARBRARGRARA
SCHEMBL8767092 0.80 RARB (0.52) MEN1KMT2ARARBRARGRARA
SCHEMBL9318235 0.80 RARB (0.48) MEN1KMT2ARARBRARGRARA
SCHEMBL9079136 0.80 RARB (0.51) MEN1KMT2ARARBRARGRARA
SCHEMBL9318119 0.79 RARB (0.44) MEN1KMT2ARARBRARGRARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0584191-A1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS. CIRD GALDERMA (FR) 1994-03-02 EP claimed