SCHEMBL7744702

SCHEMBL7744702

O=C(O)c1ccc2ccccc2c1-c1ccc(O)c(C23CC4CC(CC(C4)C2)C3)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 9/20 0.58
RARG P13631 7/20 0.58
RARA P10276 6/20 0.58
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
KDM4E B2RXH2 1/20 0.58
ALDH1A1 P00352 1/20 0.58
TP53 P04637 1/20 0.58
CYP3A4 P08684 1/20 0.58
MAPT P10636 1/20 0.58
HPGD P15428 1/20 0.58
ALOX15 P16050 1/20 0.58
ALOX12 P18054 1/20 0.58
MAPK1 P28482 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
HSD17B10 Q99714 1/20 0.58
THRB P10828 1/20 0.49
RECQL P46063 1/20 0.49
NR2E1 Q9Y466 1/20 0.49
WDR5 P61964 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9317943 0.92 WDR5 (0.51) RARBRARGRARAMEN1KMT2A
SCHEMBL9318192 0.85 MEN1 (0.46) RARBRARGRARAMEN1KMT2A
SCHEMBL4747624 0.85 RARB (0.61) RARBRARGRARAMEN1KMT2A
SCHEMBL8322288 0.83 RARB (0.49) RARBRARGRARAMEN1KMT2A
SCHEMBL8766629 0.82 RARB (0.42) RARBRARGRARAMEN1KMT2A
SCHEMBL9318235 0.81 RARB (0.48) RARBRARGRARAMEN1KMT2A
SCHEMBL9318119 0.80 RARB (0.44) RARBRARGRARAMEN1KMT2A
SCHEMBL9167076 0.80 RARB (0.60) RARBRARGRARAMEN1KMT2A
SCHEMBL9318241 0.80 RARB (0.48) RARBRARGRARAMEN1KMT2A
SCHEMBL27520679 0.79 WDR5 (0.42) RARBRARGRARAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5942531-A Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 1999-08-24 US claimed
US-5854292-A Stimulating the differentiation of preadipocytic cells and therapies based thereon CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-12-29 US claimed
US-5827897-A INSULIN-RESISTANCE IN A MAMMAL TREATED BY ADMINISTERING A SYNERGISTIC MIXTURE OF A RETINOID AND A FATTY ACID; ANTIDIABETIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-10-27 US claimed
US-5728739-A LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-03-17 US claimed
EP-0986533-A4 IDENTIFICATION OF A UNIQUE RECEPTOR SPECIFIC FOR A PARTICULAR RETINOID INDUCING CELLULAR APOPTOSIS GALDERMA RES & DEV (FR) 2001-05-23 EP disclosed
EP-0986533-A1 IDENTIFICATION OF A UNIQUE RECEPTOR SPECIFIC FOR A PARTICULAR RETINOID INDUCING CELLULAR APOPTOSIS Galderma Research & Development, S.N.C. (FR) 2000-03-22 EP disclosed
US-5942531-A Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) 1999-08-24 US disclosed
US-5854292-A Stimulating the differentiation of preadipocytic cells and therapies based thereon CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-12-29 US disclosed
US-5827897-A INSULIN-RESISTANCE IN A MAMMAL TREATED BY ADMINISTERING A SYNERGISTIC MIXTURE OF A RETINOID AND A FATTY ACID; ANTIDIABETIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-10-27 US disclosed
WO-1998037053-A1 IDENTIFICATION OF A UNIQUE RECEPTOR SPECIFIC FOR A PARTICULAR RETINOID INDUCING CELLULAR APOPTOSIS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 1998-08-27 WO disclosed
US-5767148-A 4-((5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHYL) CARBONYLBENZOIC ACID ETHYLENE ACETAL AND 4-((5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHYL) CARBOXYLAMIDOBENZOIC ACID HAVING RETINOID ACTIVITYP; LEUKEMIA CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-06-16 US disclosed
US-5728739-A LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-03-17 US disclosed
EP-0584191-A1 NOVEL AROMATIC AND POLYCYCLIC COMPOUNDS AND THEIR USE IN HUMAN OR VETERINARY MEDECINE AND IN COSMETICS. CIRD GALDERMA (FR) 1994-03-02 EP disclosed