Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303326 | 0.89 | ALOX5 (0.38) | ALOX5AGTR1 | |
| SCHEMBL9320103 | 0.88 | SLC6A3 (0.43) | ALOX5CYP4F2CYP4A11MAPTKMT2A | |
| SCHEMBL9571330 | 0.86 | CYP4F2 (0.53) | ALOX5CYP4F2CYP4A11PLK1MEN1 | |
| SCHEMBL9318344 | 0.85 | CYP4F2 (0.36) | ALOX5CYP4F2CYP4A11ACHEAR | |
| SCHEMBL9318354 | 0.84 | KDM4E (0.45) | ALOX5ARMAPTMEN1KMT2A | |
| SCHEMBL9710750 | 0.84 | HSP90AA1 (0.38) | MEN1KMT2AAKT1KDM4EALDH1A1 | |
| SCHEMBL7303338 | 0.82 | AR (0.34) | ALOX5CYP4F2CYP4A11ACHEAR | |
| SCHEMBL8548495 | 0.77 | MEN1 (0.35) | ALOX5MAPTMEN1KMT2AAGTR1 | |
| SCHEMBL8544446 | 0.77 | HTT (0.45) | ALOX5KMT2AAGTR1KDM4EALDH1A1 | |
| SCHEMBL9313939 | 0.75 | ALOX5 (0.50) | ALOX5CYP4F2CYP4A11PLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| WO-1992020679-A1 | BENZOFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |