Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.30 |
| ▸ | CHRNG | P07510 | 1/20 | 0.30 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | CHRND | Q07001 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL931210 | 0.88 | BACE1 (0.47) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL946218 | 0.82 | BACE1 (0.49) | BACE1KCNH2CTSDBACE2CHRNA1 | |
| SCHEMBL932141 | 0.80 | BACE1 (0.45) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932230 | 0.76 | BACE1 (0.59) | BACE1KCNH2BACE2 | |
| SCHEMBL931281 | 0.73 | BACE1 (0.60) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL932626 | 0.72 | BACE1 (0.65) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL945501 | 0.70 | BACE1 (0.47) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL931802 | 0.69 | BACE1 (0.38) | BACE1KCNH2CTSDBACE2CHRNA1 | |
| SCHEMBL932676 | 0.68 | MAPT (0.38) | BACE1CTSDBACE2 | |
| SCHEMBL932274 | 0.67 | BACE1 (0.43) | BACE1KCNH2BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |