Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932073 | 0.87 | BACE1 (0.59) | BACE1CTSDL3MBTL3L3MBTL1L3MBTL4 | |
| SCHEMBL931210 | 0.82 | BACE1 (0.47) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL931852 | 0.80 | BACE1 (0.49) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL6891103 | 0.74 | BACE1 (0.56) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL932230 | 0.70 | BACE1 (0.59) | BACE1KCNH2BACE2 | |
| SCHEMBL932637 | 0.70 | BACE1 (0.86) | BACE1KCNH2BACE2 | |
| SCHEMBL6894163 | 0.70 | BACE1 (0.43) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL931281 | 0.69 | BACE1 (0.60) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL932626 | 0.68 | BACE1 (0.65) | BACE1CTSDKCNH2BACE2 | |
| SCHEMBL23852239 | 0.68 | ALDH1A1 (0.43) | BACE1CTSDL3MBTL3L3MBTL1L3MBTL4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002408-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |