Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30859022 | 0.83 | LMNA (0.49) | LMNAALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL30859038 | 0.83 | PNP (0.52) | LMNAALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL29261642 | 0.83 | PNP (0.52) | LMNAALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL9656488 | 0.81 | LMNA (0.53) | LMNAALDH1A1MAPTTP53THRB | |
| SCHEMBL9737638 | 0.80 | LMNA (0.50) | LMNAALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL9319874 | 0.80 | MAPT (0.43) | LMNAALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL30859032 | 0.76 | SMN1; SMN2 (0.48) | LMNAALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL29261618 | 0.76 | SMN1; SMN2 (0.48) | LMNAALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL6491571 | 0.76 | KMT2A (0.38) | LMNAALDH1A1MAPTKDM4ETP53 | |
| SCHEMBL27030031 | 0.74 | MET (0.47) | LMNATSHRHPGDCNR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5317023-A | 2-Phenyl-(imidazo(4,5-b)pyridyl-methyl-) derivatives; hypertensive agents; cognition activators | GLAXO GROUP LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| WO-1992020679-A1 | BENZOFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1992-11-26 | — | — | WO | disclosed |
| EP-0514197-A1 | Anti-hypertensive benzofuran derivatives substituted by N-imidazolyl-methyl groups which are condensed with optionally nitrogen containing, six-membered rings | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |