Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9318966 | 0.88 | CTRC (0.43) | CTRCPPARGPTGESALOX5PTGS2 | |
| SCHEMBL30639267 | 0.80 | CTRC (0.54) | CTRCPPARGPTGESALOX5PPARA | |
| SCHEMBL4269734 | 0.80 | PTGS2 (0.42) | PPARGPTGS2MMP2MMP9MMP12 | |
| SCHEMBL9318032 | 0.80 | CYSLTR2 (0.52) | CTRCPPARGPTGESALOX5PTGS2 | |
| SCHEMBL9318284 | 0.79 | PTGS2 (0.54) | CTRCPTGS2CYSLTR2CYSLTR1ALDH1A1 | |
| SCHEMBL568454 | 0.78 | CTRC (0.50) | CTRCPPARGPTGESALOX5PPARA | |
| SCHEMBL568643 | 0.78 | CTRC (0.50) | CTRCPPARGPTGESALOX5PPARA | |
| SCHEMBL9318912 | 0.78 | PTGS2 (0.59) | CTRCPTGS2CYSLTR2CYSLTR1 | |
| SCHEMBL19717843 | 0.77 | KDM4E (0.56) | CTRCPPARGPTGESALOX5PTGS2 | |
| SCHEMBL547407 | 0.77 | KDM4E (0.56) | CTRCPPARGPTGESALOX5PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0576603-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF PROSTATIC HYPERPLASIA, CONTAINING A 5 ALPHA-REDUCTASE INHIBITOR AND AN ANTIANDROGEN | MERCK & CO. INC. (US) | 1994-01-05 | — | — | EP | disclosed |