SCHEMBL4269734

SCHEMBL4269734

CCCCCCCC(CC(=O)O)Sc1ccccc1OC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.42
PPARA Q07869 2/20 0.42
PPARG P37231 2/20 0.42
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP12 P39900 1/20 0.41
CYSLTR2 Q9NS75 2/20 0.40
CYSLTR1 Q9Y271 2/20 0.40
GPR84 Q9NQS5 4/20 0.40
CYP3A4 P08684 2/20 0.40
HTR1A P08908 2/20 0.40
CYP2C8 P10632 2/20 0.40
CYP2D6 P10635 2/20 0.40
CYP2A6 P11509 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2B6 P20813 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2E1 P05181 1/20 0.40
LTA4H P09960 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4414978 0.90 TAS1R3 (0.42) PTGS2PPARAPPARG
SCHEMBL9319017 0.80 CTRC (0.42) PTGS2PPARAPPARGMMP2MMP9
SCHEMBL7067078 0.77 MMP9 (0.46) PPARAPPARGMMP2MMP9CYSLTR2
SCHEMBL4265985 0.76 PPARG (0.62) PPARAPPARG
SCHEMBL8128981 0.75 POLB (0.55) PPARAPPARGMMP2MMP9MMP12
SCHEMBL9318966 0.74 CTRC (0.43) PTGS2PPARAPPARGMMP2MMP9
SCHEMBL19732878 0.74 GPR84 (0.44) PPARAPPARGMMP2MMP9MMP12
SCHEMBL4266898 0.73 PPARG (0.52) PPARAPPARG
SCHEMBL10424846 0.73 ITGB3 (0.47)
SCHEMBL9107162 0.72 MMP2 (0.47) MMP2MMP9MMP12GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2046736-A1 ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Emisphere Technologies, Inc. (US) 2009-04-15 EP claimed
WO-2008014430-A1 ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECHNOLOGIES, INC. (US) 2008-01-31 WO claimed
EP-2046736-A1 ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Emisphere Technologies, Inc. (US) 2009-04-15 EP disclosed
WO-2008014430-A1 ARYLSULFANYL COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS EMISPHERE TECHNOLOGIES, INC. (US) 2008-01-31 WO disclosed