Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | ACHE | P22303 | 2/20 | 0.60 |
| ▸ | SCN1A | P35498 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9320762 | 0.88 | ACHE (0.56) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| SCHEMBL9320763 | 0.84 | ACHE (0.58) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| SCHEMBL28936060 | 0.83 | ADRA1A (0.65) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| SCHEMBL23414454 | 0.83 | ADRA1A (0.59) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL7786034 | 0.81 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL1043727 | 0.81 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL29763696 | 0.81 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| SCHEMBL9320152 | 0.81 | ACHE (0.58) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL4258100 | 0.81 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 | |
| Methoxamine SCHEMBL146222 | 0.81 | ADRA1A (1.00) | ADRA1AADRA2ACYP2D6MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0440887-B1 | Improvement in the total synthesis of Erbstatin analogs | ERBA CARLO SPA (IT) | 1994-01-26 | — | — | EP | disclosed |
| US-5130472-A | TOTAL SYNTHESIS OF ERBSTATIN ANALOGS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-07-14 | — | — | US | disclosed |
| EP-0440887-A1 | Improvement in the total synthesis of Erbstatin analogs | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-08-14 | — | — | EP | disclosed |