Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TKT | P29401 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478879 | 0.91 | LMNA (0.63) | LMNAALDH1A1CYP1A2TSHRTKT | |
| SCHEMBL29895545 | 0.91 | LMNA (0.63) | LMNAALDH1A1CYP1A2TSHRTKT | |
| Hydrogen Sulfide SCHEMBL28870746 | 0.89 | LMNA (0.61) | LMNAALDH1A1CYP1A2TSHRTKT | |
| Hydrochloric Acid SCHEMBL479404 | 0.89 | LMNA (0.61) | LMNAALDH1A1CYP1A2TSHRTKT | |
| SCHEMBL4112287 | 0.82 | LMNA (0.54) | LMNANFKB1BLMPMP22ALDH1A1 | |
| SCHEMBL15534393 | 0.79 | LMNA (0.59) | LMNANFKB1BLMPMP22ALDH1A1 | |
| SCHEMBL12346332 | 0.79 | LMNA (0.63) | LMNAALDH1A1CYP1A2TSHRTKT | |
| SCHEMBL28002533 | 0.79 | LMNA (0.54) | LMNANFKB1BLMPMP22ALDH1A1 | |
| SCHEMBL479344 | 0.77 | LMNA (0.61) | LMNAALDH1A1TKTKDM4EHSP90AA1 | |
| SCHEMBL1158072 | 0.77 | LMNA (0.49) | LMNANFKB1BLMPMP22ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290888-B1 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES (JP) | 1994-01-26 | — | — | EP | claimed |
| US-5037982-A | Salt formation with carbon dioxide, heating to recover pure form with solvent | UBE INDUSTRIES, LTD. (JP) | 1991-08-06 | — | — | US | claimed |
| US-4892948-A | 2-methyl-4-amino-5-aminomethylpyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | claimed |
| EP-0290888-A2 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1988-11-17 | — | — | EP | claimed |
| JP-63284164-A | — | — | None | — | — | JP | disclosed |
| EP-0290888-B1 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES (JP) | 1994-01-26 | — | — | EP | disclosed |
| EP-0290888-B1 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES (JP) | 1994-01-26 | — | — | EP | disclosed |
| US-5037982-A | Salt formation with carbon dioxide, heating to recover pure form with solvent | UBE INDUSTRIES, LTD. (JP) | 1991-08-06 | — | — | US | disclosed |
| US-4892948-A | 2-methyl-4-amino-5-aminomethylpyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| US-4892948-A | 2-methyl-4-amino-5-aminomethylpyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| US-4892948-A | 2-methyl-4-amino-5-aminomethylpyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1990-01-09 | — | — | US | disclosed |
| JP-S63284164-A | 2-METHYL-4-AMINO-5-AMINOMETHYLPYRIMIDINE CARBONATE AND ITS PRODUCTION | UBE IND LTD | 1988-11-21 | — | — | JP | disclosed |
| EP-0290888-A2 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1988-11-17 | — | — | EP | disclosed |
| EP-0290888-A2 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1988-11-17 | — | — | EP | disclosed |
| EP-0290888-A2 | 2-Methyl-4-amino-5-aminomethyl-pyrimidine carbonate, process for preparing the same and method of purification of 2-methyl-4-amino-5-aminomethylpyrimidine using the same | UBE INDUSTRIES, LTD. (JP) | 1988-11-17 | — | — | EP | disclosed |
| EP-0280938-A1 | Antioxidant aromatic fluorophosphites | ALBEMARLE CORPORATION (US) | 1988-09-07 | — | — | EP | disclosed |