⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31607448 | 0.97 | LMNA (0.43) | — | |
| SCHEMBL3112474 | 0.97 | LMNA (0.43) | — | |
| SCHEMBL669828 | 0.92 | — | — | |
| SCHEMBL10535502 | 0.82 | LMNA (0.59) | — | |
| SCHEMBL10535505 | 0.82 | LMNA (0.59) | — | |
| SCHEMBL336892 | 0.79 | — | — | |
| SCHEMBL3109956 | 0.77 | LMNA (0.35) | — | |
| SCHEMBL9717073 | 0.77 | LMNA (0.59) | — | |
| SCHEMBL9756796 | 0.77 | LMNA (0.59) | — | |
| SCHEMBL9017128 | 0.77 | LMNA (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250074866-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. | 2025-03-06 | — | — | US | disclosed |
| US-12077483-B2 | Modified amine lipids | INTELLIA THERAPEUTICS, INC. (US) | 2024-09-03 | — | — | US | disclosed |
| US-20220119341-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. | 2022-04-21 | — | — | US | disclosed |
| EP-3891127-A1 | MODIFIED AMINE LIPIDS | Intellia Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |
| WO-2020118041-A1 | MODIFIED AMINE LIPIDS | INTELLIA THERAPEUTICS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |
| US-9670244-B2 | Oxysterol compounds and the hedgehog pathway | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| EP-1993558-B1 | OXYSTEROL COMPOUNDS AND THE HEDGEHOG PATHWAY | UNIV CALIFORNIA (US) | 2014-07-30 | — | — | EP | disclosed |
| US-8283482-B2 | Method for producing cross-coupling compound | KAO CORPORATION (JP) | 2012-10-09 | — | — | US | disclosed |
| US-8022052-B2 | Inhibition of PPAR gamma expression by specific osteogenic oxysterols | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-09-20 | — | — | US | disclosed |
| WO-2011006087-A1 | INHIBITION OF PPAR GAMMA EXPRESSION IN PREADIPOCYTE CELLS BY OXYSTEROLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-13 | — | — | WO | disclosed |
| US-20030225276-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | BLACK LAWRENCE A (US) | 2003-12-04 | — | — | US | disclosed |
| US-20020028938-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | BLACK LAWRENCE A (US) | 2002-03-07 | — | — | US | disclosed |
| US-20020013318-A1 | Prostaglandin endoperoxide H synthase biosynthesis inhibitors | BLACK LAWRENCE A (US) | 2002-01-31 | — | — | US | disclosed |
| US-6307047-B1 | PYRIDAZINONE COMPOUNDS; INHIBITORS OF CYCLOOXYGENASE-2 (COX-2); SELECTIVITY OF THESE COMPOUNDS FOR COX-2 MINIMIZES THE UNWANTED GI AND RENAL SIDE-EFFECTS SEEN WITH CURRENTLY MARKETED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS | ABBOTT LABORATORIES | 2001-10-23 | — | — | US | disclosed |
| EP-1124804-A1 | PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-1007515-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | Abbott Laboratories (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-2000024719-A1 | PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |
| WO-1999010331-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-03-04 | — | — | WO | disclosed |
| US-4089865-A | Certain thiazole compounds | SYNTEX (U.S.A.) INC. (US) | 1978-05-16 | — | — | US | disclosed |
| US-4001421-A | THIAZOLE CARDIOVASCULAR AGENTS | SYNTEX (U.S.A.) INC. (US) | 1977-01-04 | — | — | US | disclosed |