Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 4/20 | 0.52 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.52 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.52 |
| ▸ | ANPEP | P15144 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | CPA3 | P15088 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7117596 | 0.98 | ANPEP (0.56) | ANPEPTAAR1SIGMAR1SLC6A2MAOA | |
| SCHEMBL4785594 | 0.83 | SIGMAR1 (0.64) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL8072287 | 0.78 | SIGMAR1 (0.58) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL199315 | 0.76 | TRPA1 (0.57) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL28051645 | 0.76 | TRPA1 (0.57) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| Benzene SCHEMBL3082124 | 0.76 | TRPA1 (0.57) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL28785111 | 0.76 | SIGMAR1 (0.56) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 | |
| SCHEMBL24325406 | 0.76 | CYP1A2 (0.52) | TAAR1SIGMAR1CYP2D6 | |
| SCHEMBL919467 | 0.76 | TSHR (0.46) | MEN1KMT2A | |
| SCHEMBL94628 | 0.74 | TAAR1 (0.54) | TAAR1SIGMAR1SLC6A2MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0190054-B2 | Heat-processable color photosensitive material | KONISHIROKU PHOTO IND (JP) | 1994-01-12 | — | — | EP | disclosed |
| US-5071740-A | HEAT DEVELOPABLE COLOR PHOTOSENSITIVE MATERIAL | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1991-12-10 | — | — | US | disclosed |
| EP-0173584-B1 | HEAT-DEVELOPABLE COLOR PHOTO-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1990-03-07 | — | — | EP | disclosed |
| EP-0174177-B1 | HEAT-DEVELOPABLE COLOR PHOTO-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1989-11-29 | — | — | EP | disclosed |
| EP-0190054-B1 | HEAT-PROCESSABLE COLOR PHOTOSENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1989-04-19 | — | — | EP | disclosed |
| US-4656124-A | CYAN-FORMING POLYMERIC CHROMOGEN FOR DIFFUSION TRANSFER; SHARPNESS | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1987-04-07 | — | — | US | disclosed |
| US-4650748-A | POLYMERIC DYES | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1987-03-17 | — | — | US | disclosed |
| US-4631251-A | Heat-developable color photo-sensitive material with polymeric coupler | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-12-23 | — | — | US | disclosed |
| EP-0190054-A2 | Heat-processable color photosensitive material | KONICA CORPORATION (JP) | 1986-08-06 | — | — | EP | disclosed |
| EP-0186494-A2 | Heat-developable color photo-sensitive material | KONICA CORPORATION (JP) | 1986-07-02 | — | — | EP | disclosed |
| EP-0174177-A2 | Heat-developable color photo-sensitive material | KONICA CORPORATION (JP) | 1986-03-12 | — | — | EP | disclosed |
| EP-0173584-A2 | Heat-developable color photo-sensitive material | KONICA CORPORATION (JP) | 1986-03-05 | — | — | EP | disclosed |
| EP-0157639-A2 | Heat-developable multilayered color photo-sensitive material | KONICA CORPORATION (JP) | 1985-10-09 | — | — | EP | disclosed |