SCHEMBL9320932

SCHEMBL9320932

CCOC(=O)C(c1ccc(C)cc1)N(C)C(=O)Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.53

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 2/20 0.47
OPRD1 P41143 2/20 0.47
OPRK1 P41145 2/20 0.47
ALDH1A1 P00352 1/20 0.47
TP53 P04637 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
TSHR P16473 1/20 0.47
MAPK1 P28482 1/20 0.47
CYP2C19 P33261 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
UTS2R Q9UKP6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9320920 0.93 OPRM1 (0.47) OPRM1OPRD1OPRK1
SCHEMBL9321299 0.90
SCHEMBL9319108 0.85 OPRD1 (0.50) OPRM1OPRD1OPRK1ALDH1A1TP53
SCHEMBL9321286 0.84 TSHR (0.45) TSHRSMN1; SMN2
SCHEMBL9319470 0.82 OPRM1 (0.49) OPRM1OPRD1OPRK1ALDH1A1TP53
SCHEMBL9320919 0.82 OPRM1 (0.50) OPRM1OPRD1OPRK1ALDH1A1TP53
SCHEMBL9319787 0.80 AKR1B1 (0.40) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL9319873 0.80 CYP3A4 (0.45) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9319227 0.77 TSHR (0.45) TSHRSMN1; SMN2
SCHEMBL9321113 0.77 SMN1; SMN2 (0.38) TP53CYP1A2CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5350861-A Insecticides, acaricides, fungicides, antimycotic agents BAYER AKTIENGESELLSCHAFT (DE) 1994-09-27 US disclosed