SCHEMBL9322212

SCHEMBL9322212

CCOC(=O)NC(Cc1ccccc1)c1cccnc1

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.53
CYP1A2 P05177 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
HTT P42858 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
ALDH1A1 P00352 1/20 0.45
NCOA1 Q15788 1/20 0.45
NCOA3 Q9Y6Q9 1/20 0.45
TACR1 P25103 1/20 0.45
TSHR P16473 1/20 0.44
GAA P10253 1/20 0.44
ECE1 P42892 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CTSL P07711 1/20 0.43
CTSB P07858 1/20 0.43
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5696567 0.87 ALDH1A1 (0.57) HTTSMN1; SMN2ALDH1A1NCOA1NCOA3
SCHEMBL25861843 0.80 SMN1; SMN2 (0.51) CYP3A4HTTSMN1; SMN2ALDH1A1TSHR
SCHEMBL30382515 0.80 SMN1; SMN2 (0.51) CYP3A4HTTSMN1; SMN2ALDH1A1TSHR
SCHEMBL10889278 0.80 ALDH1A1 (0.52) CYP2D6CYP2C19HTTSMN1; SMN2ALDH1A1
SCHEMBL9321486 0.79 HTT (0.55) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL9322729 0.78 HTT (0.53) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL5230808 0.76 ADRB1 (0.52) CYP3A4HTTSMN1; SMN2ALDH1A1TSHR
SCHEMBL15173868 0.76 ACACB (0.60)
SCHEMBL8866135 0.76 CYP1A2 (0.63) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL5154307 0.75 ALDH1A1 (0.46) CYP3A4HTTSMN1; SMN2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0278090-B1 2-Aminoacetamide pyridinyl derivatives FISONS CORP (US) 1994-01-26 EP disclosed
US-4769466-A 2-aminoacetamide pyridinyl derivatives PENNWALT CORPORATION (US) 1988-09-06 US disclosed
EP-0278090-A2 2-Aminoacetamide pyridinyl derivatives FISONS CORPORATION (US) 1988-08-17 EP disclosed