Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.56 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.45 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxeladin SCHEMBL405412 | 0.80 | CYP2D6 (0.62) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| Hydrochloric Acid SCHEMBL9326917 | 0.80 | KMT2A (0.51) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| SCHEMBL10925808 | 0.79 | LMNA (0.51) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL9323625 | 0.77 | CHRM2 (0.53) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| SCHEMBL9324861 | 0.76 | CYP2D6 (0.48) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| SCHEMBL6758063 | 0.75 | CYP2C19 (0.55) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| SCHEMBL27506956 | 0.73 | ALDH1A1 (0.47) | CYP1A2CYP2D6KDM4EMEN1KMT2A | |
| SCHEMBL1076574 | 0.72 | TSHR (0.50) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| Alverine SCHEMBL352008 | 0.72 | KDM4E (1.00) | CYP1A2CYP2D6KDM4ELMNAMEN1 | |
| Citric Acid SCHEMBL2064710 | 0.72 | ALDH1A1 (0.68) | CYP1A2CYP2D6KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5308735-A | Aromatic-aldehyde resins, improved solubility | NIPPON PAINT CO., LTD. (JP) | 1994-05-03 | — | — | US | disclosed |
| EP-0540016-A1 | Photosensitive resin and resin composition for lithographic printing | Nippon Paint Co., Ltd. (JP) | 1993-05-05 | — | — | EP | disclosed |