Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Atipamezole SCHEMBL881064 | 0.88 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1B | |
| Atipamezole SCHEMBL31147780 | 0.86 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1B | |
| Atipamezole SCHEMBL3526769 | 0.86 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325667 | 0.81 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325681 | 0.81 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1B | |
| Hydrochloric Acid SCHEMBL9325923 | 0.80 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1B | |
| Atipamezole SCHEMBL31034927 | 0.79 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8611699 | 0.76 | ADRA2A (0.34) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9431991 | 0.75 | NPSR1 (0.40) | ALOX12 | |
| SCHEMBL9325885 | 0.75 | ADRA2A (0.35) | ADRA2AADRA2BADRA2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372954-B1 | Substituted imidazole derivatives and their preparation and use | ORION YHTYMAE OY (FI) | 1994-03-09 | — | — | EP | disclosed |
| US-5292887-A | Antgonists at postsynoptic adrenoreceptors; hypotensive and antidiabetic agents | FARMOS-YHTYMA OY (FI) | 1994-03-08 | — | — | US | disclosed |