Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613975 | 0.81 | KDM4E (0.30) | KMT2A | |
| SCHEMBL27261929 | 0.78 | ADRA2A (0.32) | ADRA2AADRA2BADRA2CADRA1B | |
| Atipamezole SCHEMBL881064 | 0.78 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1BKMT2A | |
| Atipamezole SCHEMBL31147780 | 0.77 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1BKMT2A | |
| Atipamezole SCHEMBL3526769 | 0.77 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1BKMT2A | |
| SCHEMBL8610780 | 0.77 | PNMT (0.43) | ADRA2AADRA2BADRA2C | |
| SCHEMBL9325632 | 0.76 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL9325667 | 0.75 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1B | |
| SCHEMBL8616201 | 0.74 | KDM4E (0.39) | — | |
| SCHEMBL9325681 | 0.74 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618906-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | JUVANTIA PHARMA LTD OY (FI) | 1998-04-22 | — | — | EP | disclosed |
| US-5498623-A | MULTISTAGE REACTION FOR HALOGENATION OF COMPOUNDS, NITRATION, REDUCTION AND CONVERSION TO DIAZONIUM SALT THEN HALOGENATION FOR COGNITIVE DISORDERS | ORION-YHTYMA OY (FI) | 1996-03-12 | — | — | US | disclosed |