Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 18/20 | 0.64 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201748 | 0.87 | SLC6A4 (0.65) | AKR1B1HTR2AHTR2CSLC6A4 | |
| SCHEMBL8956759 | 0.75 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1GLO1MAPT | |
| SCHEMBL8956792 | 0.75 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1GLO1MAPT | |
| SCHEMBL8956786 | 0.75 | AKR1B1 (0.66) | AKR1B1AKR1B10AKR1A1GLO1MAPT | |
| SCHEMBL9218605 | 0.74 | AKR1B1 (0.65) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL9212517 | 0.74 | KMT2A (0.79) | AKR1B1AKR1B10AKR1A1GLO1MAPT | |
| SCHEMBL9200165 | 0.72 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL9327258 | 0.71 | MAPT (0.78) | AKR1B1MAPT | |
| SCHEMBL9195206 | 0.71 | AKR1B1 (1.00) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL23447718 | 0.70 | LMNA (0.74) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304557-A | Aldose reductase inhibitor | PFIZER INC. (US) | 1994-04-19 | — | — | US | disclosed |