Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 7/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9310529 | 0.98 | HTR2C (0.58) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL5138820 | 0.98 | HTR2C (0.58) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL14085318 | 0.81 | NISCH (0.41) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL6812900 | 0.80 | HTR6 (0.56) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL9032554 | 0.80 | HTR2C (0.58) | HTR2CMAPTDRD2SIGMAR1HTR6 | |
| SCHEMBL19297061 | 0.80 | HTR2C (0.53) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL6551566 | 0.77 | HTR6 (0.62) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL7166811 | 0.76 | SLC6A3 (0.44) | KDM4EALDH1A1MAPTHSD17B10GAA | |
| SCHEMBL7538898 | 0.74 | HTR2C (0.66) | HTR2CKDM4EALDH1A1MAPTDRD2 | |
| SCHEMBL1106949 | 0.74 | HTR2C (0.61) | HTR2CKDM4EALDH1A1MAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5292761-A | Piperidine, tetrahydropyridine and pyrrolidine compounds | ADIR ET COMPAGNIE (FR) | 1994-03-08 | — | — | US | disclosed |
| US-5260317-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5250544-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1993-10-05 | — | — | US | disclosed |