Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | DRD2 | P14416 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653742 | 0.79 | KDM4E (1.00) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL29379037 | 0.79 | KDM4E (1.00) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL9310529 | 0.76 | HTR2C (0.58) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL5138820 | 0.76 | HTR2C (0.58) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL11134482 | 0.75 | HTR2A (0.53) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL19297061 | 0.74 | HTR2C (0.53) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| Bromide SCHEMBL9325877 | 0.74 | HTR2C (0.56) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL20540332 | 0.73 | PIK3CD (0.64) | HTR6ADRB1MAPK1PIK3CD | |
| SCHEMBL10124857 | 0.73 | CDK9 (0.49) | HTR2CKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL5008976 | 0.72 | SLC6A4 (0.68) | KDM4EHSD17B10ALOX15HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | disclosed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067237-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | HTR2C 1/4885KDM4E 1147/4885ALDH1A1 663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.