Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9839348 | 0.83 | HPGD (0.53) | MAPTCNR2MEN1HPGDKMT2A | |
| SCHEMBL9325277 | 0.73 | EPHX2 (0.53) | CNR2EPHX2CNR1ALDH1A1HPGD | |
| SCHEMBL9325149 | 0.71 | EPHX1 (0.49) | EPHX2ALDH1A1 | |
| SCHEMBL9324994 | 0.70 | TRPV1 (0.33) | TSHRTRPV1 | |
| Bromide SCHEMBL28346796 | 0.68 | CASP2 (0.65) | EPHX2CNR1 | |
| SCHEMBL9840062 | 0.68 | HTR1A (0.53) | LMNATSHRALDH1A1HPGDTRPV1 | |
| SCHEMBL19661686 | 0.68 | CASP2 (0.63) | MAPTCNR2EPHX2CNR1MEN1 | |
| SCHEMBL25933495 | 0.68 | HDAC3 (0.57) | GPR119CNR1LMNATSHRALDH1A1 | |
| SCHEMBL18683587 | 0.67 | EPHX2 (0.62) | EPHX2CNR1 | |
| SCHEMBL21970952 | 0.67 | CNR1 (0.65) | MAPTCNR2EPHX2CNR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |