SCHEMBL9326316

SCHEMBL9326316

Cc1cc(-c2cc(C)c(N)c(-c3ccccc3)c2)cc(-c2ccccc2)c1N

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.54
CYP3A4 P08684 2/20 0.54
TSHR P16473 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
TP53 P04637 1/20 0.54
ESR2 Q92731 1/20 0.44
HSD17B10 Q99714 2/20 0.43
IKBKB O14920 4/20 0.42
CHUK O15111 4/20 0.42
IKBKE Q14164 1/20 0.42
PKMYT1 Q99640 1/20 0.42
CYP2A6 P11509 1/20 0.42
CYP2B6 P20813 1/20 0.42
PDE4A P27815 1/20 0.42
PDE4B Q07343 1/20 0.42
PDE4C Q08493 1/20 0.42
PDE4D Q08499 1/20 0.42
PDE3B Q13370 1/20 0.42
PDE3A Q14432 1/20 0.42
DHFR P00374 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22517389 0.98 ALDH1A1 (0.52) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL22554778 0.96 ALDH1A1 (0.50) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL30818025 0.85 NUDT1 (0.47) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL6586695 0.85 NUDT1 (0.47) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL807863 0.84 ALDH1A1 (0.70) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL5016738 0.84 HSD17B10 (0.52) ALDH1A1CYP3A4TDP1HSD17B10IKBKB
SCHEMBL22554727 0.82 ALDH1A1 (0.67) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL22554699 0.82 ALDH1A1 (0.67) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL19857180 0.82 METAP2 (0.40) ALDH1A1CYP3A4TSHRTDP1TP53
SCHEMBL15975997 0.82 ESR2 (0.44) ALDH1A1CYP3A4TSHRTDP1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0407172-B1 Aromatic polyimide separation membrane MITSUBISHI CHEM IND (JP) 1994-02-23 EP disclosed
US-5112941-A A fluorinated membranes with high selectivity MITSUBISHI KASEI CORPORATION (JP) 1992-05-12 US disclosed
EP-0437611-A1 SEPARATIVE MEMBRANE MADE OF AROMATIC POLYIMIDE MITSUBISHI KASEI CORPORATION (JP) 1991-07-24 EP disclosed
EP-0407172-A1 Aromatic polyimide separation membrane MITSUBISHI KASEI CORPORATION (JP) 1991-01-09 EP disclosed