Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325624 | 0.95 | KCNH2 (0.48) | NPC1RAB9AKCNH2CHRM2DRD3 | |
| SCHEMBL9324382 | 0.86 | KDM4E (0.39) | KCNH2CHRM2DRD3CACNA1FACHE | |
| SCHEMBL9326394 | 0.82 | LTA4H (0.41) | NPC1RAB9AKCNH2DRD3LTA4H | |
| SCHEMBL9325729 | 0.80 | CYP2C9 (0.45) | SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL9326050 | 0.78 | SMN1; SMN2 (0.43) | KCNH2SMN1; SMN2LMNA | |
| SCHEMBL9325409 | 0.76 | TDP1 (0.40) | NPC1RAB9AKCNH2DRD3LTA4H | |
| SCHEMBL9326379 | 0.74 | KCNH2 (0.50) | RAB9AKCNH2MAPK1 | |
| SCHEMBL9325797 | 0.73 | KDM4E (0.40) | NPC1RAB9AKCNH2CHRM2DRD3 | |
| SCHEMBL10426270 | 0.73 | NPC1 (0.68) | NPC1RAB9AKCNH2CHRM2DRD3 | |
| SCHEMBL14113144 | 0.69 | NPC1 (0.93) | NPC1RAB9AKCNH2CHRM2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |