Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9324382 | 0.87 | KDM4E (0.39) | KDM4EKCNH2DRD3CACNA1FCHRM2 | |
| SCHEMBL9326474 | 0.83 | LMNA (0.44) | KDM4EKCNH2DRD3CACNA1FCHRM2 | |
| SCHEMBL9326153 | 0.82 | DRD2 (0.37) | KCNH2DRD3HTR2ADRD2OPRM1 | |
| SCHEMBL9325771 | 0.80 | KCNH2 (0.50) | KCNH2DRD3DRD2 | |
| SCHEMBL9326401 | 0.73 | NPC1 (0.48) | KCNH2DRD3CACNA1FCHRM2CACNA1D | |
| SCHEMBL10896046 | 0.73 | KCNH2 (0.53) | KDM4EKCNH2DRD3CACNA1FCHRM2 | |
| SCHEMBL3719859 | 0.72 | KCNH2 (0.57) | KDM4EKCNH2DRD3CACNA1FCHRM2 | |
| SCHEMBL9325624 | 0.70 | KCNH2 (0.48) | KCNH2DRD3CACNA1FCHRM2CACNA1D | |
| SCHEMBL10878888 | 0.70 | KCNH2 (0.54) | KDM4EKCNH2DRD3CACNA1FCHRM2 | |
| SCHEMBL9624530 | 0.70 | KDM4E (0.58) | KDM4EKCNH2DRD3CACNA1FCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |