Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 5/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326394 | 0.94 | LTA4H (0.41) | TDP1LTA4HTRPM8RAB9AMEN1 | |
| SCHEMBL9326379 | 0.83 | KCNH2 (0.50) | RAB9AMEN1MAPTKMT2AKCNH2 | |
| SCHEMBL9325624 | 0.82 | KCNH2 (0.48) | LTA4HRAB9ANPC1CYP2D6DRD3 | |
| SCHEMBL9324433 | 0.80 | SIGMAR1 (0.39) | MAPTTSHRCYP2D6DRD2DRD3 | |
| SCHEMBL9325440 | 0.78 | TAAR1 (0.43) | DRD2DRD3OPRK1 | |
| SCHEMBL9326401 | 0.76 | NPC1 (0.48) | LTA4HRAB9ANPC1DRD3HTR1A | |
| SCHEMBL9325760 | 0.74 | CA12 (0.46) | CYP2D6CYP3A4 | |
| SCHEMBL9327603 | 0.74 | LMNA (0.53) | RAB9ATSHRNPC1CYP2C19CYP3A4 | |
| SCHEMBL9325455 | 0.71 | HTR2A (0.39) | RAB9AMEN1MAPTKMT2ADRD2 | |
| SCHEMBL8808576 | 0.68 | MAOB (0.56) | TDP1RAB9AMAPTTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310941-A | Antiarrythmia agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-05-10 | — | — | US | disclosed |
| US-5208252-A | Antiarrhythmia | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-04 | — | — | US | disclosed |