Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 9/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985047 | 0.94 | PRKCA (0.40) | LMNAPRKCAPDCD4PTPN1 | |
| SCHEMBL9282825 | 0.93 | PPARG (0.39) | LMNAPRKCAPDCD4 | |
| SCHEMBL8985099 | 0.93 | FFAR4 (0.38) | LMNAPRKCAMAPK1PDCD4PTPN1 | |
| SCHEMBL9745619 | 0.93 | PRKCA (0.37) | LMNAPRKCAMAPTMAPK1PDCD4 | |
| SCHEMBL9671370 | 0.88 | PTPN1 (0.46) | PTPN1 | |
| SCHEMBL9327053 | 0.88 | PTPN1 (0.43) | PRKCAPTPN1 | |
| SCHEMBL8985060 | 0.88 | LMNA (0.49) | LMNAPRKCAMAPTALDH1A1 | |
| SCHEMBL9671381 | 0.88 | PDCD4 (0.47) | PDCD4 | |
| SCHEMBL14339054 | 0.88 | PDCD4 (0.47) | PDCD4 | |
| SCHEMBL7294590 | 0.88 | PDCD4 (0.47) | PDCD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| EP-0295056-B1 | ANTI-INFLAMMATORY FURANONES | ALLERGAN, INC (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| EP-0295056-A1 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1988-12-14 | — | — | EP | disclosed |