SCHEMBL9327249

SCHEMBL9327249

O=C(O)c1cccc(C(=O)c2ccc(S(=O)(=O)c3ccc(C(=O)c4cccc(C(=O)O)c4C(=O)O)cc3)cc2)c1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
CA9 Q16790 2/20 0.55
AKR1C3 P42330 3/20 0.52
CDC25B P30305 2/20 0.50
ATM Q13315 1/20 0.50
NR4A1 P22736 1/20 0.49
CDC25A P30304 1/20 0.46
HSD17B10 Q99714 1/20 0.46
APEX1 P27695 2/20 0.43
POLB P06746 2/20 0.43
KDM4E B2RXH2 2/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MYC P01106 1/20 0.43
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL425272 0.88 AKR1C3 (0.65) CA1CA2CA9AKR1C3CDC25B
SCHEMBL23501588 0.84 AKR1C3 (0.61) CA1CA2CA9AKR1C3CDC25B
SCHEMBL144047 0.82 AKR1C3 (0.76) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL30978151 0.82 AKR1C3 (0.76) AKR1C3CDC25BATMNR4A1CDC25A
Hydrochloric Acid SCHEMBL10626938 0.80 AKR1C3 (0.73) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL21247044 0.79 AKR1C3 (0.55) CA1CA2CA9AKR1C3CDC25B
SCHEMBL147496 0.78 CDC25B (0.55) CA1CA2CA9AKR1C3CDC25B
SCHEMBL29882813 0.78 CDC25B (0.55) CA1CA2CA9AKR1C3CDC25B
SCHEMBL426276 0.77 AKR1C3 (0.61) AKR1C3CDC25BATMNR4A1CDC25A
SCHEMBL4915957 0.77 HNF4A (0.46) CA1CA2CA9CDC25BATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0359340-B1 Spirodilactam polymers SHELL INT RESEARCH (NL) 1994-03-16 EP disclosed
US-5028688-A Polyamideimide polymers SHELL OIL COMPANY (US) 1991-07-02 US disclosed
US-4978736-A Polyamideimide polymers SHELL OIL COMPANY (US) 1990-12-18 US disclosed
EP-0359340-A2 Spirodilactam polymers SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1990-03-21 EP disclosed