Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | FBP1 | P09467 | 5/20 | 0.53 |
| ▸ | TLR4 | O00206 | 1/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | JUN | P05412 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | ABL2 | P42684 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872640 | 1.00 | RXRA (0.58) | RXRAFBP1TLR4TLR2NFKB1 | |
| SCHEMBL29960004 | 1.00 | RXRA (0.58) | RXRAFBP1TLR4TLR2NFKB1 | |
| SCHEMBL1805981 | 0.85 | RXRA (0.54) | RXRAFBP1TLR4TLR2EGFR | |
| SCHEMBL1805984 | 0.85 | RXRA (0.54) | RXRAFBP1TLR4TLR2EGFR | |
| SCHEMBL13930333 | 0.78 | RXRA (0.59) | RXRAFBP1TLR4TLR2EGFR | |
| SCHEMBL8413165 | 0.77 | MAPT (0.62) | NFKB1MAPTLMNATRPA1NPC1 | |
| SCHEMBL104148 | 0.76 | HSP90AA1 (0.63) | RXRAFBP1TLR4TLR2MAPT | |
| SCHEMBL470811 | 0.76 | NFE2L2 (0.58) | RXRAFBP1TLR4TLR2NFE2L2 | |
| SCHEMBL798354 | 0.76 | RXRA (0.58) | RXRAFBP1TLR4TLR2MAPT | |
| SCHEMBL4723192 | 0.76 | NFE2L2 (0.58) | RXRAFBP1TLR4TLR2NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116693552-A | Polycyclic dihydrobenzofuran compound and preparation method thereof | 浙江大学 | 2023-09-05 | — | — | CN | claimed |
| CN-110041340-B | 6-aryl-benzofuran carbazole compounds and preparation and application thereof | 浙江大学 | 2020-12-18 | — | — | CN | claimed |
| CN-101851222-A | Synthetic method of 2-amido-3-nitrile-4-nitromethyl-4H-chromene and derivative thereof | UNIV ZHEJIANG NORMAL | 2010-10-06 | — | — | CN | claimed |
| CN-116693552-A | Polycyclic dihydrobenzofuran compound and preparation method thereof | 浙江大学 | 2023-09-05 | — | — | CN | disclosed |
| CN-116693552-A | Polycyclic dihydrobenzofuran compound and preparation method thereof | 浙江大学 | 2023-09-05 | — | — | CN | disclosed |
| CN-114746103-A | Rapafucin derivative compounds and methods of use thereof | 约翰霍普金斯大学 | 2022-07-12 | — | — | CN | disclosed |
| CN-110041340-B | 6-aryl-benzofuran carbazole compounds and preparation and application thereof | 浙江大学 | 2020-12-18 | — | — | CN | disclosed |
| CN-110041340-B | 6-aryl-benzofuran carbazole compounds and preparation and application thereof | 浙江大学 | 2020-12-18 | — | — | CN | disclosed |
| CN-106083959-B | 1,4(-NO2), 5- tri- replaces 1,2,3- triazole glycoconjugate and its derivative | 武汉工程大学 | 2019-05-28 | — | — | CN | disclosed |
| CN-106046087-B | 1,5- bis- replaces 1,2,3- triazole glycoconjugate and its derivative | 武汉工程大学 | 2019-05-03 | — | — | CN | disclosed |
| CN-106083959-A | 1,4 (NO2), 5 three replacement 1,2,3 triazole glycoconjugate and derivants thereof | 武汉工程大学 | 2016-11-09 | — | — | CN | disclosed |
| CN-103497108-A | Synthesis method of p-hydroxy-beta-nitrostyrene | UNIV NORTH CHINA | 2014-01-08 | — | — | CN | disclosed |
| US-8497242-B2 | Processes for intermediates for macrocyclic compounds | TRANZYME PHARMA INC. (CA) | 2013-07-30 | — | — | US | disclosed |
| CN-101851222-A | Synthetic method of 2-amido-3-nitrile-4-nitromethyl-4H-chromene and derivative thereof | UNIV ZHEJIANG NORMAL | 2010-10-06 | — | — | CN | disclosed |
| CN-101851222-A | Synthetic method of 2-amido-3-nitrile-4-nitromethyl-4H-chromene and derivative thereof | UNIV ZHEJIANG NORMAL | 2010-10-06 | — | — | CN | disclosed |
| EP-0375723-B1 | SUBSTRATES FOR THE ASSAY OF ENZYMES | KING S COLLEGE LONDON (GB) | 1994-03-23 | — | — | EP | disclosed |
| US-5221606-A | REAGENT AND KIT FOR ENZYME ASSAY COMPRISING A SUBSTRATE CONSONANT WITH GIVEN ENZYME TO BE ASSAYED | KING'S COLLEGE LONDON (GB) | 1993-06-22 | — | — | US | disclosed |
| EP-0375723-A1 | SUBSTRATES FOR THE ASSAY OF ENZYMES. | KING S COLLEGE LONDON (GB) | 1990-07-04 | — | — | EP | disclosed |
| EP-0346912-A2 | Sugar ester derivatives, reagents for measurement of hydrolase activity and methods for measurement of hydrolase activity | Toyo Boseki Kabushiki Kaisha (JP) | 1989-12-20 | — | — | EP | disclosed |
| WO-1989002473-A1 | SUBSTRATES FOR THE ASSAY OF ENZYMES | KING'S COLLEGE LONDON (GB) | 1989-03-23 | — | — | WO | disclosed |