Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.52 |
| ▸ | CCND1 | P24385 | 4/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25798842 | 0.85 | CDK4 (0.45) | CDK4CCND1HTR1DHTR2AHTR2C | |
| SCHEMBL29372496 | 0.82 | CDK4 (0.76) | CDK4CCND1HTR2AHTR2CMAPK1 | |
| SCHEMBL3595410 | 0.82 | CDK4 (0.76) | CDK4CCND1HTR2AHTR2CMAPK1 | |
| Iodide SCHEMBL2581030 | 0.81 | CDK4 (0.73) | CDK4CCND1HTR2AHTR2CMAPK1 | |
| SCHEMBL29670034 | 0.78 | HTR2A (0.42) | CDK4CCND1HTR2AHTR2C | |
| SCHEMBL108285 | 0.78 | HTR2A (0.42) | CDK4CCND1HTR2AHTR2C | |
| SCHEMBL18307589 | 0.77 | CDK4 (0.52) | CDK4CCND1HTR2AHTR2CMAPK1 | |
| SCHEMBL18857024 | 0.75 | MTNR1A (0.62) | HTR2AHTR2CGRM2HTR6 | |
| SCHEMBL17676473 | 0.74 | HTR2A (0.58) | CDK4CCND1HTR2AHTR2C | |
| SCHEMBL19173629 | 0.74 | HTR2A (0.58) | CDK4CCND1HTR1DHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586553-A1 | CARBOXAMIDO-(3,2N)-CARBOCYCLIC-2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1994-03-16 | — | — | EP | claimed |