Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2080518 | 0.85 | TSHR (0.51) | TSHRHTTKDM4EALDH1A1HPGD | |
| SCHEMBL6903284 | 0.84 | TSHR (0.58) | TSHRHTTKDM4EALDH1A1HPGD | |
| SCHEMBL2129167 | 0.82 | TSHR (0.47) | TSHRHTTKDM4EALDH1A1HPGD | |
| SCHEMBL30415135 | 0.82 | HTT (0.57) | TSHRHTTALDH1A1HPGDMAPT | |
| SCHEMBL308733 | 0.82 | HTT (0.57) | TSHRHTTALDH1A1HPGDMAPT | |
| SCHEMBL9343951 | 0.82 | MAPT (0.47) | KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL2778140 | 0.81 | HTT (0.56) | TSHRHTTALDH1A1HPGDMAPT | |
| SCHEMBL6566957 | 0.81 | TSHR (0.55) | TSHRHTTKDM4EALDH1A1HPGD | |
| SCHEMBL6075765 | 0.81 | TSHR (0.46) | TSHRHTTKDM4EALDH1A1HPGD | |
| SCHEMBL16486722 | 0.80 | TSHR (0.54) | TSHRHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304549-A | Control or prevention of degenerative joint diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | disclosed |
| US-4120688-A | AMINOMETHYLPHOSPHONIC ACID | THE PROCTOR & GAMBLE COMPANY (US) | 1978-10-17 | — | — | US | disclosed |