Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.64 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327282 | 0.78 | ADORA2A (1.00) | ADORA2AADORA3ADORA1ADORA2BCSNK1D | |
| SCHEMBL9326962 | 0.76 | ADORA2A (0.98) | ADORA2AADORA3ADORA1ADORA2BCSNK1D | |
| SCHEMBL29117428 | 0.76 | SMN1; SMN2 (0.46) | KDM4EALDH1A1GAAGFERMAPT | |
| SCHEMBL9327228 | 0.76 | ADORA2A (0.67) | ADORA2AADORA3ADORA1ADORA2BCSNK1D | |
| SCHEMBL9327253 | 0.75 | ADORA2A (0.48) | ADORA2AADORA3ADORA1ADORA2BCSNK1D | |
| SCHEMBL9327337 | 0.75 | ADORA2A (0.69) | ADORA2AADORA3ADORA1ADORA2BCSNK1D | |
| SCHEMBL7240698 | 0.71 | KDM4E (0.49) | KDM4EALDH1A1GAAGFERMAPT | |
| SCHEMBL9328560 | 0.70 | ADORA3 (0.58) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL30596777 | 0.69 | KDM4E (0.41) | ADORA2AADORA3ADORA1ADORA2BKDM4E | |
| SCHEMBL30596780 | 0.69 | KDM4E (0.41) | ADORA2AADORA3ADORA1ADORA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356894-A | Adenosine antagonists | SYNGENTA LIMITED (GB) | 1994-10-18 | — | — | US | disclosed |
| US-5270311-A | [1,2,4]-Triazolo[1,5-a]and pyrazolo[2,3-a][1,3,5]triazine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-14 | — | — | US | disclosed |
| EP-0459702-A1 | Azole Derivatives | ZENECA LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |