Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24416092 | 0.85 | HRH4 (0.74) | HRH4L3MBTL1CA12CA1CA2 | |
| SCHEMBL30250290 | 0.82 | GPR6 (0.57) | HRH4L3MBTL1BCL2L1HDAC6HDAC3 | |
| SCHEMBL18071180 | 0.82 | HRH4 (1.00) | HRH4L3MBTL1CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL29268510 | 0.81 | GPR6 (0.56) | HRH4L3MBTL1BCL2L1HDAC6HDAC3 | |
| Ethylene SCHEMBL8547383 | 0.81 | HRH4 (0.68) | HRH4L3MBTL1CA12CA1CA2 | |
| SCHEMBL12353720 | 0.79 | ALDH1A1 (0.78) | HRH4L3MBTL1ALDH1A1POLB | |
| SCHEMBL7536818 | 0.79 | HRH4 (0.69) | HRH4L3MBTL1CA12CA1CA2 | |
| SCHEMBL16599230 | 0.78 | HRH4 (0.67) | HRH4L3MBTL1CA12CA1CA2 | |
| SCHEMBL4814960 | 0.77 | HRH4 (0.67) | HRH4L3MBTL1CA12CA1CA2 | |
| SCHEMBL4814970 | 0.77 | HRH4 (0.67) | HRH4L3MBTL1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296212-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296212-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-8648067-B2 | Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-8648067-B2 | Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC. (US) | 2014-02-11 | — | — | US | disclosed |
| US-20120238551-A1 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON FRANCE (FR) | 2012-09-20 | — | — | US | disclosed |
| US-20120238551-A1 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON FRANCE (FR) | 2012-09-20 | — | — | US | disclosed |
| EP-2459529-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | Cephalon, Inc. (US) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011002984-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002984-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296212-A1 | SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | HRH3, HRH4, HRH2 | HRH4 2/4885L3MBTL1 4844/4885CA12 3670/4885 |
| US-20120238551-A1 | Substituted Phenoxypropylcycloamine Derivatives as Histamine-3 (H3) Receptor Ligands | HRH3, HRH4, HRH2 | HRH4 2/4885L3MBTL1 4844/4885CA12 3670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.