Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | DPP4 | P27487 | 2/20 | 0.67 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12918735 | 0.86 | HRH4 (0.67) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL933006 | 0.85 | HRH4 (0.70) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL18071180 | 0.85 | HRH4 (1.00) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL5160678 | 0.84 | HRH4 (0.54) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| Ethylene SCHEMBL8547383 | 0.84 | HRH4 (0.68) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL5161325 | 0.82 | HRH4 (0.56) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL7536818 | 0.81 | HRH4 (0.69) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL18051806 | 0.81 | L3MBTL1 (0.61) | HRH4L3MBTL1DPP4DPP8POLB | |
| SCHEMBL6232921 | 0.81 | ALDH1A1 (0.66) | HRH4L3MBTL1DPP4DPP8ALDH1A1 | |
| SCHEMBL16599230 | 0.80 | HRH4 (0.67) | HRH4L3MBTL1DPP4DPP8CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2023-04-13 | — | — | US | disclosed |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | VALO HEALTH, INC. (US) | 2022-10-25 | — | — | US | disclosed |
| US-20220144793-A1 | WATER-SOLUBLE YNAMIDE COUPLING REAGENT AND PREPARATION METHOD AND USE THEREOF | Xi'an Easy Peptide Biotechnology Co., Ltd. (CN) | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144793-A1 | WATER-SOLUBLE YNAMIDE COUPLING REAGENT AND PREPARATION METHOD AND USE THEREOF | SRMS, SYK, SRM | HRH4 3405/4885L3MBTL1 3391/4885DPP4 1663/4885 |
| US-20230110003-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | HRH4 2277/4885L3MBTL1 4177/4885DPP4 1494/4885 |
| US-11479564-B2 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) | NAMPT, NAPRT, NNMT | HRH4 2277/4885L3MBTL1 4177/4885DPP4 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.