Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PPIB | P23284 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330271 | 1.00 | PPID (0.52) | PPIDALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL9333566 | 0.79 | ALDH1A1 (0.43) | PPIDALDH1A1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL19209521 | 0.79 | MAPT (0.66) | ALDH1A1NPSR1HTTSMN1; SMN2LMNA | |
| SCHEMBL9542426 | 0.79 | MAPT (0.66) | ALDH1A1NPSR1HTTSMN1; SMN2LMNA | |
| SCHEMBL13901447 | 0.76 | PPID (0.55) | PPIDALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL3899535 | 0.74 | HSD11B1 (0.61) | PPIDALDH1A1HSD11B1MMP2POLB | |
| SCHEMBL10908450 | 0.72 | PPID (0.57) | PPIDALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL20733397 | 0.70 | ALDH1A1 (0.65) | ALDH1A1NPSR1HTTSMN1; SMN2LMNA | |
| SCHEMBL9845673 | 0.70 | ALDH1A1 (0.65) | ALDH1A1NPSR1HTTSMN1; SMN2LMNA | |
| SCHEMBL28980625 | 0.70 | ALDH1A1 (0.65) | ALDH1A1NPSR1HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214045-A | Acrylamides having amide substituted by residues of glycine, alanine, aspartic acid, methionine, proline or thiazolidinecarboxylic acid and acrylic group substituted by phenylthio-, phenylsulfinyl- or phenylsulfonyl-groups | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1993-05-25 | — | — | US | claimed |
| EP-0408106-B1 | Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine | RICHTER GEDEON VEGYESZET (HU) | 1994-04-06 | — | — | EP | disclosed |
| US-5214045-A | Acrylamides having amide substituted by residues of glycine, alanine, aspartic acid, methionine, proline or thiazolidinecarboxylic acid and acrylic group substituted by phenylthio-, phenylsulfinyl- or phenylsulfonyl-groups | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1993-05-25 | — | — | US | disclosed |
| EP-0408106-A2 | Novel acrylic amide derivatives, a process for their preparation, pharmaceutical compositions containing the same and their use in medicine | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1991-01-16 | — | — | EP | disclosed |