SCHEMBL9330385

SCHEMBL9330385

Nc1ccccc1OC1=CCC(Oc2ccccc2N)(c2ccccc2)C=C1

nearest known ligand 0.37

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
GAA P10253 2/20 0.33
ALDH1A1 P00352 2/20 0.33
RCE1 Q9Y256 1/20 0.32
ADRA2B P18089 1/20 0.31
PTGS1 P23219 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27194864 0.76 GLA (0.33) GAA
SCHEMBL534636 0.76 MAOA (0.41) MAPTGAAALDH1A1TDP1
SCHEMBL20945337 0.69 MEN1 (0.30)
SCHEMBL28899333 0.63
SCHEMBL31688135 0.62 ALDH1A1 (0.33) KDM4EMAPTCRHBPCRHR2ALDH1A1
SCHEMBL9714800 0.62
SCHEMBL31231403 0.62 ALDH1A1 (0.36) KDM4EMAPTCRHBPCRHR2GAA
SCHEMBL29508342 0.62 KDM4E (0.65) KDM4EMAPTCRHBPCRHR2GAA
SCHEMBL30979203 0.62 KDM4E (0.65) KDM4EMAPTCRHBPCRHR2GAA
SCHEMBL81185 0.62 KDM4E (0.65) KDM4EMAPTCRHBPCRHR2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0400811-B1 Copolyimide gas separation membranes derived from substituted methylene dianilines and unsubstituted diamines DU PONT (US) 1994-04-13 EP disclosed
EP-0400811-A1 Copolyimide gas separation membranes derived from substituted methylene dianilines and unsubstituted diamines E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-05 EP disclosed
US-4932983-A Copolyimide gas separation membranes derived from substituted methylene dianilines and unsubstituted diamines E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-06-12 US disclosed