SCHEMBL9330591

SCHEMBL9330591

Nc1cccc(-n2c(=O)c3ccc(cc3)c2=O)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.55
CASP1 P29466 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
ALDH1A1 P00352 2/20 0.55
KDM4E B2RXH2 1/20 0.55
ALOX15 P16050 1/20 0.55
CASP7 P55210 1/20 0.55
DDB1 Q16531 1/20 0.45
CRBN Q96SW2 1/20 0.45
ADRA2C P18825 1/20 0.43
CYP3A4 P08684 1/20 0.42
RECQL P46063 1/20 0.42
USP2 O75604 1/20 0.41
KEAP1 Q14145 1/20 0.41
NFE2L2 Q16236 1/20 0.41
TDP2 O95551 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
PDE4A P27815 1/20 0.40
PDE4B Q07343 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9275063 0.84 KDM4E (0.55) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL4967461 0.81 ALDH1A1 (0.61) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL13779281 0.71 ALDH1A1 (1.00) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL14100097 0.71 CYP1A2 (0.68) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL24452764 0.69 MGLL (0.72) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL8761154 0.69 ALDH1A1 (0.58) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL29829630 0.68 KDM4E (0.59) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL6536863 0.68 ALDH1A1 (0.55) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL6798021 0.68 L3MBTL1 (0.61) MAPTCASP1MEN1KMT2AALDH1A1
SCHEMBL29789020 0.68 KDM4E (0.59) MAPTCASP1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61195127-A None JP disclosed
EP-0193374-B1 Thermoplastic aromatic polyamideimide copolymers and process for their preparation TORAY INDUSTRIES (JP) 1994-04-13 EP disclosed
US-4831104-A MOLDING MATERIALS TORAY INDUSTRIES, INC. (JP) 1989-05-16 US disclosed
EP-0193374-A2 Thermoplastic aromatic polyamideimide copolymers and process for their preparation TORAY INDUSTRIES, INC. (JP) 1986-09-03 EP disclosed
JP-S61195127-A TEHRMOPLASTIC AROMATIC POLYAMIDE IMIDE COPOLYMER TORAY IND INC 1986-08-29 JP disclosed