Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.51 |
| ▸ | CASR | P41180 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330171 | 0.90 | CYP2D6 (0.58) | CYP2D6ADRB2ADRB1ADRB3CASR | |
| SCHEMBL8734022 | 0.85 | CYP2D6 (0.52) | CYP2D6ADRB2ADRB1ADRB3CASR | |
| SCHEMBL8728061 | 0.80 | ADRB2 (0.49) | CYP2D6ADRB2ADRB1ADRB3CASR | |
| SCHEMBL8733094 | 0.77 | ADRB3 (0.46) | CYP2D6ADRB2ADRB1ADRB3CASR | |
| SCHEMBL8733133 | 0.76 | ABCB1 (0.47) | CYP2D6ADRB2ADRB1ADRB3CASR | |
| SCHEMBL22957897 | 0.76 | CYP2D6 (1.00) | CYP2D6ADRB2ADRB1ADRB3CASR | |
| SCHEMBL8071295 | 0.75 | RIPK1 (0.45) | MAPTHTTSMN1; SMN2 | |
| SCHEMBL9330183 | 0.75 | CYP2D6 (0.51) | CYP2D6ADRB2ADRB1ADRB3MAPT | |
| Hydrochloric Acid SCHEMBL10589406 | 0.74 | RIPK1 (0.44) | MAPTHTTSMN1; SMN2 | |
| SCHEMBL11373388 | 0.74 | CYP2D6 (0.77) | CYP2D6ADRB2ADRB1ADRB3CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0328251-B1 | 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamides and processes and intermediates for their preparation | ICI PLC (GB) | 1994-04-13 | — | — | EP | disclosed |
| EP-0328251-A2 | 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamides and processes and intermediates for their preparation | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-08-16 | — | — | EP | disclosed |