Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728061 | 0.85 | ADRB2 (0.49) | ADRB2ADRB1ADRB3ITGB3ITGA2B | |
| SCHEMBL8734022 | 0.84 | CYP2D6 (0.52) | ADRB2ADRB1ADRB3ITGB3ITGA2B | |
| SCHEMBL8733140 | 0.84 | KDM4E (0.42) | ABCB1KMT2AMEN1KDM4ELMNA | |
| SCHEMBL8733094 | 0.80 | ADRB3 (0.46) | ADRB2ADRB1ADRB3CYP2D6RAD52 | |
| SCHEMBL9330596 | 0.76 | CYP2D6 (0.60) | ADRB2ADRB1ADRB3ITGB3ITGA2B | |
| SCHEMBL23403561 | 0.75 | RAB9A (0.50) | ABCB1ADRB2ADRB1ADRB3CYP2D6 | |
| SCHEMBL22806689 | 0.75 | ABCB1 (0.52) | ABCB1ADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL22806688 | 0.75 | ABCB1 (0.52) | ABCB1ADRB2ADRB1ADRB3KMT2A | |
| SCHEMBL21634023 | 0.74 | ADRB2 (0.63) | ADRB2ADRB1ADRB3CYP2D6SLC6A2 | |
| SCHEMBL29721075 | 0.74 | ADRB2 (0.63) | ADRB2ADRB1ADRB3CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726165-A | HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-03-10 | — | — | US | disclosed |