Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31406400 | 0.89 | TDP1 (0.53) | LMNAMAPTSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL28549832 | 0.81 | MAPT (0.46) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL28557786 | 0.80 | ALDH1A1 (0.47) | LMNAMAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL31730010 | 0.79 | LMNA (0.48) | LMNAMAPTSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL31748048 | 0.78 | SMN1; SMN2 (0.55) | LMNAMAPTSMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL346691 | 0.78 | LMNA (0.59) | LMNAMAPTTDP1ALDH1A1KMT2A | |
| SCHEMBL1138365 | 0.75 | KDM4E (0.47) | SMN1; SMN2ALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL11060295 | 0.75 | CYP19A1 (0.44) | MAPTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL28412030 | 0.75 | POLB (0.47) | LMNAALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL28408881 | 0.75 | HDAC4 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321273-B1 | Thioformamide derivatives | MAY & BAKER LTD (GB) | 1994-04-20 | — | — | EP | disclosed |
| US-5185375-A | For treating disorders of smooth muscle contraction, including respiratory, gastrointestinal, urogential; topical for alopecia | MAY & BAKER LIMITED (GB) | 1993-02-09 | — | — | US | disclosed |
| EP-0321273-A2 | Thioformamide derivatives | RHONE POULENC RORER LIMITED (GB) | 1989-06-21 | — | — | EP | disclosed |