Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9333178 | 0.87 | FNTA (0.46) | HRH1ALDH1A1HPGDHRH3ROCK2 | |
| SCHEMBL9333208 | 0.85 | HRH1 (0.44) | HRH1HRH4ALDH1A1HPGDHRH3 | |
| SCHEMBL9380680 | 0.80 | PTAFR (0.55) | HRH1LMNACHRM2CHRM1CHRM3 | |
| SCHEMBL14475368 | 0.78 | DRD3 (0.61) | DRD3HRH1LMNACHRM2CHRM4 | |
| SCHEMBL30471280 | 0.78 | DRD3 (0.61) | DRD3HRH1LMNACHRM2CHRM4 | |
| SCHEMBL9333210 | 0.77 | FNTA (0.52) | HRH1LMNACHRM2CHRM3HTR2A | |
| SCHEMBL9332766 | 0.76 | FNTA (0.52) | HRH1LMNACHRM2CHRM3HTR2A | |
| SCHEMBL9333282 | 0.75 | PTAFR (0.59) | HRH1LMNACHRM2CHRM3HTR2A | |
| SCHEMBL9332876 | 0.73 | FNTA (0.65) | HRH1LMNACHRM2CHRM3HTR2A | |
| SCHEMBL9039987 | 0.73 | DRD3 (0.77) | DRD3HRH1LMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5358953-A | For treatment of allergic rhinitis | PFIZER INC. (US) | 1994-10-25 | — | — | US | disclosed |
| EP-0572425-B1 | IMIDAZOPYRIDINE PAF/H 1 ANTAGONISTS | PFIZER LTD (GB) | 1994-08-03 | — | — | EP | disclosed |
| WO-1992014734-A1 | IMIDAZOPYRIDINE PAF/H1 ANTAGONISTS | PFIZER LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |