Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 11/20 | 0.54 |
| ▸ | GRM5 | P41594 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029278 | 0.87 | GRM5 (0.54) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL7813413 | 0.80 | MAPT (0.52) | MAOBNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL7806678 | 0.77 | MAOA (0.44) | MAOBNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL9335343 | 0.77 | MAP3K14 (0.47) | MAOBCYSLTR1 | |
| SCHEMBL7808099 | 0.75 | MAOB (0.42) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL30451384 | 0.73 | MAOB (0.50) | MAOBGRM5NPSR1 | |
| SCHEMBL69670 | 0.73 | MAOB (0.50) | MAOBGRM5NPSR1 | |
| SCHEMBL20554210 | 0.72 | MAOB (0.55) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL6836955 | 0.72 | MAOB (0.81) | MAOBGRM5NPC1ALDH1A1HPGD | |
| SCHEMBL30353218 | 0.72 | MAOB (0.81) | MAOBGRM5NPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |